INAC
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Arnaud BUHOTStructure et Propriétés d'Architectures Moléculaires  04.38.78.38.68 04.38.78.50.97
arnaud.buhot@cea.fr
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Functions
Since March 2002 : CEA research engineer
Since January 2007 : Head of the Theory Group
Proposition de Thèse
Translocation de polymères à travers un nanopore
Contacts : A. Buhot (arnaud.buhot@cea.fr) et S. Mossa (stefano.mossa@cea.fr)
Puces à Aptamères [doc]
Contacts : Y. Roupioz (yoann.roupioz@cea.fr) et A. Buhot (arnaud.buhot@cea.fr)
Reserch interests
Theory of biochips (DNA or protein microarrays)
Soft Condensed Matter
Lectures on Numerical Simulations in Statistical Mechanics
CV
Since Jan. 2007: Head of the Theory Group
Since March 2002: Research Engineer, SPrAM, INAC, CEA Grenoble
Jan. 2000 - Jan. 2002: Marie Curie Fellowship, Theoretical Physics, Oxford
Oct. 1999 - Jan. 2000: Postdoctoral Associate, Theoretical Physics, Oxford (EPSRC)
July 1998 - Sept. 1999: Research Associate, SPSMS, DRFMC, CEA Grenoble (AMN)
May 1999: PhD in Physics, Université Joseph Fourier of Grenoble
Aug. 1997 - June 1998: Research Assistant (in lieu of Mulitary Duty), LPS, ENS Paris
Sept. 1996 - Jul 1997: Research Associate, SPSMS, DRFMC, CEA Grenoble (AMN)
Sept. 1992 - Aug. 1996: Student at the Ecole Normale Supérieure of Lyon
Scientific publications
TOX4 and its binding partners recognize DNA adducts generated by platinum anticancer drugs
C. Bounaix Morand du Puch, E. Barbier, A. Kraut, Y. Couté, J. Fuchs, A. Buhot, T. Livache, M. Sève, A. Favier, T. Douki, D. Gasparutto, S. Sauvaigo and J. Breton
Archives of Biochemistry and Biophysics 507, 296-303 (2011).
On chip real time monitoring of B-cells hybridoma secretion of immunoglobulin
S. Milgram, S. Cortes, M.-B. Villiers, P. Marche, A. Buhot, T. Livache and Y. Roupioz
Biosensors and Bioelectronics 26, 2728-2732 (2011).
Viscosity and Renewal Times of Polymer Reptation Models
A. Buhot
Macromolecules 43, 9155-9159 (2010).
Salt Concentration Effects on Equilibrium Melting Curves from DNA Microarrays
J. Fuchs, J. B. fiche, A. Buhot, R. Calemczuk, T. Livache
Biophys. J. 99, 1886-1895 (2010).
Effects of formamide on the thermal stability of DNA duplexes on biochips
J. Fuchs, D. Dell'Atti, A. Buhot, R. Calemczuk, M. Mascini and T. Livache
Anal. Biochem. 397, 132-134 (2010).
SPR imaging for label-free multiplexed analyses of DNA N-glycosylase interactions with damaged DNA duplexes
C. Corne, J.B. Fiche, D. Gasparutto, V. Cunin, E. Suraniti, A. Buhot, J. Fuchs, R. Calemczuk, T. Livache and A. Favier
Analyst 133, 1036-1045 (2008).
Point Mutation Detection by Surface Plasmon Resonance Imaging Coupled with a Temperature Scan Method in a Model System
J. B. Fiche, J. Fuchs, A. Buhot, R. Calemczuk, and T. Livache
Anal. Chem. 80,1049-1057 (2008).
Stretching of homopolymeric RNA reveals single-stranded helices and base-stacking
Y. Seol, G. Skinner, K. Visscher, A. Buhot, and A. Halperin
Phys. Rev. Lett. 98, 158103 (2007).
Physics News Update, 829-2 (2007).
Temperature effects on DNA Chip Experiments from Surface Plasmon Resonance imaging: Isotherms and Melting Curves
J. B. Fiche, A. Buhot, R. Calemczuk, and T. Livache
Biophys. J. 92, 935-946 (2007).
Faculty of 1000 Biology evaluation
Hybridization at a Surface: The Role of Spacers in DNA Microarrays
A. Halperin, A. Buhot and E. B. Zhulina
Lagnmuir 22, 11290-11304 (2006).
On the Hybirdization Isotherms of DNA Microarrays: The Langmuir Model and its Extensions
A. Halperin, A. Buhot and E. B. Zhulina
J. Phys. Condens. Matter 18, S463-S490 (2006).
Exact curvilinear diffusion coefficients in the repton model
A. Buhot
Eur. Phys. J. E 18, 239-244 (2005).
Brush Effects on DNA Chips: Thermodynamics, Kinetics and Design Guidelines
A. Halperin, A. Buhot and E. B. Zhulina
Biophys. J. 89, 796-811 (2005).
Cluster algorithm for nonadditive hard-core mixtures
A. Buhot
J. Chem. Phys. 122, 024105 (2005).
Hybridization Isotherms of DNA Microarrays and the Quantification of Mutation Studies
A. Halperin, A. Buhot and E. B. Zhulina
Clin. Chem. 50, 2254-2262 (2004).
Effects of stacking on the configurations and elasticity of single-stranded nucleic acids
A. Buhot and A. Halperin
Phys. Rev. E 70, 020902(R) (2004).
Sensitivity, specificity and the hybridization isotherms of DNA chips
A. Halperin, A. Buhot and E. B. Zhulina
Biophys. J. 86, 718-730 (2004).
Kovacs effect and fluctuation-dissipation relations in 1D kinetically constrained models
A. Buhot
J. Phys. A: Math. Gen. 36, 12367-12377 (2003).
Simple strong glass forming models: mean-field solution with activation
A. Buhot, J. P. Garrahan and D. Sherrington
J. Phys. A: Math. Gen. 36, 307-328 (2003).
Fluctuation-Dissipation Relations in the Activated Regime of Simple Strong-Glass Models
A. Buhot and J. P. Garrahan
Phys. Rev. Lett. 88, 225702 (2002).
Extension Behavior of Helicogenic Polypeptides
A. Buhot and A. Halperin
Macromolecules 35, 3238-3252 (2002).
Crossover from fragile to strong glassy behaviour in the spin facilitated chain model
A. Buhot and J. P. Garrahan
J. Phys.: Condens. Matter 14, 1499-1507 (2002).
Glassy behaviour in simple kinetically constrained models: topological networks, lattice analogues and annihilation-diffusion
D. Sherrington, L. Davison, A. Buhot and J. P. Garrahan
J. Phys.: Condens. Matter 14, 1673-1682 (2002).
Rigorous Bounds to Retarded Learning
A. Buhot, M. B. Gordon and J. P. Nadal
Phys. Rev. Lett. 88, 099801 (2002).
Comment to D. Herschkowitz and M. Opper, Phys. Rev. Lett. 86, 2174 (2001).
Crossover from Fragile to Strong Glassy Behaviour in Kinetically Constrained Systems
A. Buhot and J. P. Garrahan
Phys. Rev. E 64, 021505 (2001).
Glassy behaviour in a 3-state spin model
L. Davison, D. Sherrington, J. P. Garrahan and A. Buhot
J. Phys. A: Math. Gen. 34, 5147-5182 (2001).
Robust learning and generalization with Support Vector Machines
A. Buhot and M. B. Gordon
J. Phys. A: Math. Gen. 34, 4377-4388 (2001).
On the Helix-Coil transition in grafted chains
A. Buhot and A. Halperin
Europhys. Lett. 50, 756-761 (2000).
Storage capacity of a constructive learning algorithm
A. Buhot and M. B. Gordon
J. Phys. A: Math. Gen. 33, 1713-1727 (2000).
The Extension of Rod-Coil Multiblock Copolymers and the Effect of the Helix-Coil Transition
A. Buhot and A. Halperin
Phys. Rev. Lett. 84, 2160-2163 (2000).
A reply to the Comment by A. A. Louis on Phys. Rev. Lett. 82, 960 (1999).
A. Buhot
Phys. Rev. Lett. 84, 1841 (2000).
Phase separation in two-dimensional additive mixtures
A. Buhot and W. Krauth
Phys. Rev. E 59, 2939-2941 (1999).
Packing fraction at the phase separation transition in hard-core mixtures
A. Buhot
Phys. Rev. Lett. 82, 960-963 (1999).
Bayesian learning versus optimal learning
M. B. Gordon and A. Buhot
Physica A 257, 85-98 (1998).
Numerical Solution of Hard-Core Mixtures
A. Buhot and W. Krauth
Phys. Rev. Lett. 80, 3787-3790 (1998).
Phys. Rev. Focus 1, story 11, May 4, 1998.
Phase transitions in optimal unsupervised learning
A. Buhot and M. B. Gordon
Phys. Rev. E 57, 3326-3333 (1998).
Finite size scaling of the Bayesian perceptron
A. Buhot, J.-M. Torres-Moreno and M. B. Gordon
Phys. Rev. E 55, 7434-7440 (1997).
Cost function and patterns distribution of the bayesian perceptron
A. Buhot and M. B. Gordon
Phys. Lett. A 228, 73-78 (1997).
Precise study of some number fields and Galois actions occurring in conformal field theory
E. Buffenoir, A. Coste, J. Lascoux, P. Degiovanni, A. Buhot
Annales de l'institut Henri Poincaré (A) Physique théorique, 63, 41-79 (1995).
Proceedings
Storage Capacity of the Tilinglike Learning Algorithm
A. Buhot and M. B. Gordon
Proceedings of the Conference Disordered and Complex Systems, pages 17-22,
King's College, London, July 2000
Statistical mechanics of support vector machines
A. Buhot and M. B. Gordon
Proceedings ESANN'99, 201-206 (1999)
Detection of two Gaussian clusters
A. Buhot and M. B. Gordon
Proceedings ESANN'99, 327-332 (1999).
Numerical simulations of an optimal algorithm for supervised learning
A. Buhot, J.-M. Torres-Moreno and M. B. Gordon
Proceedings ESANN'97, 151-156 (1997).
